rs1801265
A SNP in the DPYD gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- DPYD
- Location
- Chr 197,883,329 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 23%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1801265 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 9% A;A 56%
- European ancestry (Utah)G;G 3% A;A 72%
- Han Chinese (Beijing)G;G 0% A;A 86%
- Japanese (Tokyo)G;G <1% A;A 88%
- Yoruba (Nigeria)G;G 17% A;A 34%
- African ancestry (Southwest US)G;G 19% A;A 28%
- Chinese (Denver)G;G 0% A;A 84%
- Gujarati IndianG;G 7% A;A 46%
- Luhya (Kenya)G;G 26% A;A 28%
- Mexican ancestry (Los Angeles)G;G 10% A;A 59%
- Maasai (Kenya)G;G 12% A;A 37%
- TuscanG;G 7% A;A 60%
Related
Other DPYD SNPs
- rs1801160T;T5-fluorouracil toxicity (?)Important
- rs3918290T;T5-fluorouracil toxicity, dihydropyrimidine dehydrogenase deficiencyImportant
- rs55886062C;C5-fluorouracil toxicityImportant
- rs67376798A;A5-fluorouracil toxicityImportant
- rs1801159T;Tcommon in clinvarTypical
- rs1801268C;Ccommon genotypeTypical
- rs2297595T;Tcommon on affy axiom dataTypical
Notes
From SNPedia
Notes
Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE). Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients. Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
Source and license
Adapted from rs1801265 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.