rs55886062
A SNP in the DPYD gene on chromosome 1. Its most notable genotype is C;C: 5-fluorouracil toxicity
- Gene
- DPYD
- Location
- Chr 197,515,787 (GRCh38)
- Highest magnitude
- 3.5Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other DPYD SNPs
- rs1801160T;T5-fluorouracil toxicity (?)Important
- rs3918290T;T5-fluorouracil toxicity, dihydropyrimidine dehydrogenase deficiencyImportant
- rs67376798A;A5-fluorouracil toxicityImportant
- rs1801159T;Tcommon in clinvarTypical
- rs1801265G;Gcommon in clinvarTypical
- rs1801268C;Ccommon genotypeTypical
- rs2297595T;Tcommon on affy axiom dataTypical
Genosets
- Gs306Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).Very important
- Gs312Intermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine).Very important
- Gs313Normal DPYD activity and thus 5-FU metabolism predicted, since none of the three best described nonfunctional DPYD alleles were observed.Worth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs55886062, also known as c.1679 T>G, encodes the DPYD*13 allele of the DPYD gene on chromosome 1. Note that the terms used in the literature for this gene can be confusing, since the gene is in reverse orientation to the chromosome strand on the reference genome.
A;C
Slight possibility of being DPYD deficient, if a compound heterozygote, and therefore also at increased risk for chemotherapeutic toxicity if treated with 5-fluorouracil or other fluoropyrimidines.
C;C
You can expect toxicity from 5-fluorouracil, a common treatment for various cancers. This variation does not influence your risk of cancer.
Source and license
Adapted from rs55886062 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.