rs1801160

A SNP in the DPYD gene on chromosome 1. Its most notable genotype is T;T: 5-fluorouracil toxicity (?)

Gene
DPYD
Location
Chr 197,305,364 (GRCh38)
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad5-fluorouracil toxicity (?)Important · 3.5
  2. C;TBadPossible 5-fluorouracil toxicityWorth knowing · 2.0
  3. C;CGoodcommon/normalTypical · 0.0

SNPedia records rs1801160 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other DPYD SNPs

All DPYD SNPs

Notes

From SNPedia

Notes

rs1801160, also known as V732I or p.Val732Ile, is a variant in the DPYD gene on chromosome 1. A pharmacogenetic study of ~1,500 colon cancer patients treated with a 5-fluorouracil regimen concluded that patients with a rs1801160(A) allele were at roughly a 2-fold higher risk for an adverse effect (from the fluorouracil). The absolute frequencies of the various adverse effects varied; for example, neutropenia occurred in about 1 in 10 patients (so about 1 in 5 rs1801160(A) carriers).

Source and license

Adapted from rs1801160 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.