rs193922317
A SNP in the GCK gene on chromosome 7. Its most notable genotype is C;C: common in clinvar
- Gene
- GCK
- Location
- Chr 744,149,778 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs193922317 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other GCK SNPs
- rs104894006A;GDiabetes, late-onset noninsulin-dependent (predicted)Very important
- rs1799884T;T2.7x increased risk for Type 2 Diabetes. Mothers have babies 54g heavier.Important
- rs80356654A;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs80356655A;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894005A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894008C;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894009C;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894011A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
Notes
From SNPedia
Notes
Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online. High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Source and license
Adapted from rs193922317 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.