rs2069861

A SNP in the IL6 gene on chromosome 7. Its most notable genotype is C;C.

Gene
IL6
Location
Chr 722,732,035 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.093% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 5 HapMap populations.

  • AverageC;C 93%
  • European ancestry (Utah)C;C 83%
  • Han Chinese (Beijing)C;C 98%
  • Japanese (Tokyo)C;C 100%
  • Chinese (Denver)C;C 99%
  • TuscanC;C 86%

Other IL6 SNPs

All IL6 SNPs

Notes

From SNPedia

Show notes, about 130 words

Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis. Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance. An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Immunogenetics of seasonal influenza vaccine response. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

Source and license

Adapted from rs2069861 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.