rs2070676

A SNP in the CYP2E1 gene on chromosome 10. Its most notable genotype is G;G: CYP2E1*1B homozygote

Gene
CYP2E1
Location
Chr 10133,537,633 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.048% of people
  2. C;GNot ratedcarrier of one CYP2E1*1B alleleTypical · 0.035% of people
  3. G;GMost notableBadCYP2E1*1B homozygoteWorth knowing · 2.017% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48% C;G 35% G;G 17%
  • European ancestry (Utah)C;C 74% C;G 26% G;G 0%
  • Han Chinese (Beijing)C;C 65% C;G 34% G;G 2%
  • Japanese (Tokyo)C;C 65% C;G 34% G;G 2%
  • Yoruba (Nigeria)C;C 9% C;G 46% G;G 45%
  • African ancestry (Southwest US)C;C 16% C;G 46% G;G 39%
  • Chinese (Denver)C;C 77% C;G 23% G;G 0%
  • Gujarati IndianC;C 71% C;G 27% G;G 2%
  • Luhya (Kenya)C;C 5% C;G 40% G;G 56%
  • Mexican ancestry (Los Angeles)C;C 69% C;G 24% G;G 7%
  • Maasai (Kenya)C;C 14% C;G 50% G;G 36%
  • TuscanC;C 69% C;G 31% G;G 0%

Other CYP2E1 SNPs

All CYP2E1 SNPs

Notes

From SNPedia

Notes

rs2070676, also known as 9896C>G, is a SNP in the CYP2E1 gene. The rs2070676(G) allele defines the CYP2E1*1B variant.

Source and license

Adapted from rs2070676 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.