rs2515641

A SNP in the CYP2E1 gene on chromosome 10. Its most notable genotype is T;T: CYP2E1_10463T>C(F421F) homozygote

Gene
CYP2E1
Location
Chr 10133,537,858 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.049% of people
  2. C;TNot ratedcarrier of one CYP2E1_10463T>C(F421F) alleleTypical · 0.035% of people
  3. T;TMost notableBadCYP2E1_10463T>C(F421F) homozygoteWorth knowing · 2.016% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 49% C;T 35% T;T 16%
  • European ancestry (Utah)C;C 74% C;T 26% T;T 0%
  • Han Chinese (Beijing)C;C 65% C;T 34% T;T 2%
  • Japanese (Tokyo)C;C 65% C;T 33% T;T 2%
  • Yoruba (Nigeria)C;C 10% C;T 51% T;T 39%
  • African ancestry (Southwest US)C;C 18% C;T 46% T;T 37%
  • Chinese (Denver)C;C 77% C;T 23% T;T 0%
  • Gujarati IndianC;C 71% C;T 27% T;T 2%
  • Luhya (Kenya)C;C 5% C;T 41% T;T 55%
  • Mexican ancestry (Los Angeles)C;C 69% C;T 24% T;T 7%
  • Maasai (Kenya)C;C 14% C;T 52% T;T 34%
  • TuscanC;C 69% C;T 31% T;T 0%

Other CYP2E1 SNPs

All CYP2E1 SNPs

Notes

From SNPedia

Notes

rs2515641 is a SNP in the CYP2E1 gene. The rs2515641(T) allele defines the CYP2E1_10463T>C(F421F) variant.

Source and license

Adapted from rs2515641 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.