rs27048
A SNP in the SLC6A3 gene on chromosome 5. Its most notable genotype is C;C: 2x risk of severe alcohol withdrawal
- Gene
- SLC6A3
- Location
- Chr 51,412,530 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 33%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 51% C;T 39% T;T 10%
- European ancestry (Utah)C;C 33% C;T 43% T;T 24%
- Han Chinese (Beijing)C;C 69% C;T 28% T;T 3%
- Japanese (Tokyo)C;C 83% C;T 16% T;T <1%
- Yoruba (Nigeria)C;C 46% C;T 48% T;T 7%
- African ancestry (Southwest US)C;C 37% C;T 49% T;T 14%
- Chinese (Denver)C;C 73% C;T 24% T;T 3%
- Gujarati IndianC;C 37% C;T 48% T;T 16%
- Luhya (Kenya)C;C 49% C;T 38% T;T 13%
- Mexican ancestry (Los Angeles)C;C 50% C;T 38% T;T 12%
- Maasai (Kenya)C;C 58% C;T 36% T;T 7%
- TuscanC;C 30% C;T 60% T;T 10%
Related
Other SLC6A3 SNPs
- rs267607068T;TInfantile Parkinsonism-dystoniaVery important
- rs267607069A;AInfantile Parkinsonism-dystoniaVery important
- rs431905504T;TInfantile Parkinsonism-dystoniaVery important
- rs431905514T;TInfantile Parkinsonism-dystoniaVery important
- rs431905515G;GInfantile Parkinsonism-dystoniaVery important
- rs431905516A;AInfantile Parkinsonism-dystoniaVery important
- rs27072C;C2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.Worth knowing
- rs460000G;GBetter response to amphetamineWorth knowing
Notes
From SNPedia
Notes
[rs27048]], a SNP in the dopamine transporter SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor, rs27072. Variations in the DAT1 gene may affect the inattentive subtype of ADHD.
Source and license
Adapted from rs27048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.