rs2745557

A SNP in the PTGS2 gene on chromosome 1. Its most notable genotype is A;A: autism risk?

Gene
PTGS2
Location
Chr 1186,680,089 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedautism risk?Typical · 0.02% of people
  2. A;GNot ratedautism risk?Typical · 0.025% of people
  3. G;GGoodnormalTypical · 0.073% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 25% G;G 73%
  • European ancestry (Utah)A;A <1% A;G 23% G;G 76%
  • Han Chinese (Beijing)A;A 0% A;G 5% G;G 95%
  • Japanese (Tokyo)A;A <1% A;G 8% G;G 91%
  • Yoruba (Nigeria)A;A 3% A;G 29% G;G 69%
  • African ancestry (Southwest US)A;A 2% A;G 30% G;G 68%
  • Chinese (Denver)A;A 0% A;G 5% G;G 95%
  • Gujarati IndianA;A 4% A;G 32% G;G 64%
  • Luhya (Kenya)A;A 6% A;G 32% G;G 63%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 19% G;G 78%
  • Maasai (Kenya)A;A 5% A;G 47% G;G 47%
  • TuscanA;A 3% A;G 41% G;G 56%

Conditions, medicines and genes

Other PTGS2 SNPs

All PTGS2 SNPs

Notes

From SNPedia

Notes

A study of 151 Korean families reported that the rs2745557(A) allele of the PTGS2 gene, also known as cyclooxygenase-2 (Cox-2), was overtransmitted (p<0.01) in autism spectrum disorders.

Source and license

Adapted from rs2745557 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.