rs28928905
A SNP in the KCNH2 gene on chromosome 7. Its most notable genotype is T;T: possible association with long QT syndrome
- Gene
- KCNH2
- Location
- Chr 7150,952,514 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadpossible association with long QT syndrome
- C;TBadpossible association with long QT syndrome
- G;GNot ratedNo summary available.
- C;CGoodcommon in clinvar
SNPedia records rs28928905 on the minus strand: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other KCNH2 SNPs
- rs189014161C;GLong QT syndrome; other possible cardiac issuesVery important
- rs9333649C;TRomano-Ward Long QT SyndromeVery important
- rs12720441A;GRomano-Ward Long QT SyndromeVery important
- rs28928904A;TRomano-Ward Long QT SyndromeVery important
- rs121912505C;TRomano-Ward Long QT SyndromeVery important
- rs121912506C;TRomano-Ward Long QT SyndromeVery important
- rs121912507C;TRomano-Ward Long QT SyndromeVery important
- rs121912508A;GRomano-Ward Long QT SyndromeVery important
Notes
From SNPedia
Notes
rs28928905, also known as Ala490Thr or A490T, is a SNP in the KCNH2 gene on chromosome 7. The rs28928905(A) allele has been reported to be associated with bradycardia-induced long QT syndrome; see OMIM for discussion. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
T;T
see discussion at rs28928905
C;T
see discussion at rs28928905
Source and license
Adapted from rs28928905 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.