rs3798758
A SNP in the ESR1 gene on chromosome 6. Its most notable genotype is C;C: common in complete genomics
- Gene
- ESR1
- Location
- Chr 6152,100,719 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 13%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs3798758 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 70%
- European ancestry (Utah)C;C 93%
- Han Chinese (Beijing)C;C 54%
- Japanese (Tokyo)C;C 50%
- Yoruba (Nigeria)C;C 76%
- African ancestry (Southwest US)C;C 63%
- Chinese (Denver)C;C 51%
- Gujarati IndianC;C 72%
- Luhya (Kenya)C;C 66%
- Mexican ancestry (Los Angeles)C;C 79%
- Maasai (Kenya)C;C 78%
- TuscanC;C 89%
Related
Other ESR1 SNPs
- rs9340799G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Important
- rs104893956C;TCarrier for an estrogen resistance mutationImportant
- rs121913044A;TCarrier for an estrogen resistance mutationImportant
- rs397509428G;TCarrier for an estrogen resistance mutationImportant
- rs2881766G;TSlightly increased risk for pregnancy-induced hypertensionMinor
- rs2295190T;TSlightly increased risk for ovarian cancer in womenMinor
- rs728524A;Acommon in complete genomicsTypical
- rs2179922A;Amales 1-2cm shorter on averageTypical
Notes
From SNPedia
Notes
{{PMID Auto |PMID=19926619 |Title=Association of Estrogen Receptor {alpha} Genotypes/Haplotypes With Carotid Intima-Media Thickness in Taiwanese Women }}
Source and license
Adapted from rs3798758 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.