rs41293513
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is A;C: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,363,370 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in clinvar
- A;CMost notableBadBRCA2 variant considered pathogenic for breast cancer
- A;GBadBRCA2 variant considered pathogenic for breast cancer
- A;TBadBRCA2 variant considered pathogenic for breast cancer
On SNPedia: (A;A), (A;C), (A;G), (A;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
aka c.8168A>T (p.Asp2723Val) and also c.8168A>C (p.Asp2723Ala) as well as c.8168A>G (p.Asp2723Gly) All three are classified as BRCA2 gene pathogenic mutations for breast cancer based on likelihood cited in ClinVar and in
A;C
See details via ClinVar link on main SNP/rs# page.
A;G
See details via ClinVar link on main SNP/rs# page.
A;T
See details via ClinVar link on main SNP/rs# page.
Source and license
Adapted from rs41293513 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.