rs4251417
A SNP in the SLC6A4 gene on chromosome 17. Its most notable genotype is C;C.
- Gene
- SLC6A4
- Location
- Chr 1730,224,840 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 4%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs4251417 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageC;C 95%
- European ancestry (Utah)C;C 81%
- Han Chinese (Beijing)C;C 100%
- Japanese (Tokyo)C;C 100%
- Yoruba (Nigeria)C;C 100%
- African ancestry (Southwest US)C;C 98%
- Gujarati IndianC;C 99%
- Mexican ancestry (Los Angeles)C;C 93%
- TuscanC;C 86%
Related
Other SLC6A4 SNPs
- rs25531T;Tshort form of 5-HTTLPR. lower levels of serotonin, slightly less happy, benefits from more supportWorth knowing
- rs140701T;TIncreased risk for anxiety disordersMinor
- rs6354G;Gcommon in clinvarTypical
- rs140700G;GNo summary available.Typical
- rs1042173C;CnormalTypical
- rs2020933A;ANo summary available.Typical
- rs2020942C;Tcommon in complete genomicsTypical
- rs2066713A;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples.
Source and license
Adapted from rs4251417 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.