rs4646976

A SNP in the CYP2E1 gene on chromosome 10. Its most notable genotype is A;A: normal

Gene
CYP2E1
Location
Chr 10133,534,223 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.085% of people
  2. A;GNot ratedcarrier of one CYP2E1_marker8 alleleTypical · 0.015% of people
  3. G;GNot ratedCYP2E1_marker8 homozygoteTypical · 0.0<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 85% A;G 15% G;G <1%
  • European ancestry (Utah)A;A 96% A;G 4% G;G 0%
  • Han Chinese (Beijing)A;A 64% A;G 35% G;G <1%
  • Japanese (Tokyo)A;A 65% A;G 34% G;G 2%
  • Yoruba (Nigeria)A;A 82% A;G 18% G;G 0%
  • African ancestry (Southwest US)A;A 93% A;G 7% G;G 0%
  • Chinese (Denver)A;A 77% A;G 23% G;G 0%
  • Gujarati IndianA;A 93% A;G 6% G;G 1%
  • Luhya (Kenya)A;A 88% A;G 12% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 85% A;G 16% G;G 0%
  • Maasai (Kenya)A;A 90% A;G 9% G;G <1%
  • TuscanA;A 97% A;G 3% G;G 0%

Other CYP2E1 SNPs

All CYP2E1 SNPs

Notes

From SNPedia

Notes

rs4646976 is a SNP in the CYP2E1 gene. The rs4646976(G) allele defines the CYP2E1_marker8 variant, as used in the 2008 study determining the 16 most common CYP2E1 haplotypes world-wide.(see CYP2E1 for details)

Source and license

Adapted from rs4646976 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.