rs587776574
A SNP in the WT1 gene on chromosome 11. Its most notable genotype is -;C: Wilms tumor susceptibility (predicted)
- Gene
- WT1
- Location
- Chr 1132,399,967 (GRCh38)
- Highest magnitude
- 7.5Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;CMost notableBadWilms tumor susceptibility (predicted)
- G;GGoodcommon in clinvar
- C;CGoodcommon in clinvar
- GT;GTGoodcommon in clinvar
SNPedia records rs587776574 on the minus strand: (-;G), (C;C), (G;G), (GT;GT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other WT1 SNPs
- rs28941778C;TDenys-Drash syndromeVery important
- rs28941779A;GFrasier syndrome mutationVery important
- rs28942089A;GDenys-Drash syndromeVery important
- rs121907900A;GWilms tumor susceptibility (predicted)Very important
- rs121907906A;GWilms tumor susceptibility (predicted)Very important
- rs121907908C;TWilms tumor susceptibility (predicted)Very important
- rs121907909A;GWilms tumor susceptibility (predicted)Very important
- rs121907911G;TWilms tumor susceptibility (predicted)Very important
Notes
From SNPedia
Notes
aka c.443delG (p.Gly148Valfs)
Source and license
Adapted from rs587776574 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.