rs745456776
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is -;G: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,338,942 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;GMost notableBadBRCA2 variant considered pathogenic for breast cancer
- G;GGoodcommon in clinvar
On SNPedia: (-;-), (-;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
aka c.4587dupG (p.Lys1530Glufs) and also c.4587_4588insA; this latter term is equivalent to c.4593dupA (p.Val1532Serfs), which is rs397507732. These "insA" variants are the same but (until merged in dbSNP perhaps) come about from whether the insertion is considered to occur at the beginning or end of a run of A's. 23andMe name: i5010511
-;G
See details via ClinVar link on main SNP/rs# page.
Source and license
Adapted from rs745456776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.