rs794728455
A SNP in the KCNH2 gene on chromosome 7. Its most notable genotype is -;C: Potential cardiac arrhythmia, or, Long QT syndrome
- Gene
- KCNH2
- Location
- Chr 7150,947,795 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;CMost notableBadPotential cardiac arrhythmia, or, Long QT syndrome
SNPedia records rs794728455 on the minus strand: (-;-), (-;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other KCNH2 SNPs
- rs189014161C;GLong QT syndrome; other possible cardiac issuesVery important
- rs9333649C;TRomano-Ward Long QT SyndromeVery important
- rs12720441A;GRomano-Ward Long QT SyndromeVery important
- rs28928904A;TRomano-Ward Long QT SyndromeVery important
- rs121912505C;TRomano-Ward Long QT SyndromeVery important
- rs121912506C;TRomano-Ward Long QT SyndromeVery important
- rs121912507C;TRomano-Ward Long QT SyndromeVery important
- rs121912508A;GRomano-Ward Long QT SyndromeVery important
Notes
From SNPedia
Notes
c.2775dupG (p.Pro926Alafs) Designated in ClinVar by a single source as pathogenic for an unspecified "cardiac phenotype". Most clinically significant KCNH2 gene mutations are dominantly inherited mutations leading to Long QT syndrome, but the "cardiac phenotype" designation could also refer to a cardiac arrhythmia.
-;C
see discussion at rs794728455
Source and license
Adapted from rs794728455 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.