rs80359303
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is -;AATAA: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,333,241 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;AATAAMost notableBadBRCA2 variant considered pathogenic for breast cancer
- -;ATAABadBRCA2 variant considered pathogenic for breast cancer
- AAAT;AAATGoodcommon in clinvar
- ATAA;ATAAGoodcommon in clinvar
On SNPedia: (-;AATAA), (-;ATAA), (AAAT;AAAT), (ATAA;ATAA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
rs80359303, also known as 1991del4, c.1763_1766delATAA and p.Asn588_Lys589?fs, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar. This mutation is considered a founder mutation in the Columbian Hispanic population.
-;ATAA
See details at rs80359303.
Source and license
Adapted from rs80359303 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.