rs80359638
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is -;A: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,354,961 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;AMost notableBadBRCA2 variant considered pathogenic for breast cancer
- -;AABadBRCA2 variant considered pathogenic for breast cancer
- AA;AAGoodcommon in clinvar
On SNPedia: (-;A), (-;AA), (AA;AA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
rs80359638 represents three mutations in the BRCA2 gene, all of which are considered pathogenic in ClinVar for breast cancer. These mutations are are known by a variety of terms, including c.7110delA, c.7110dupA, c.7109_7110delAA, 7336delAA, c.7108_7109delAA and p.Lys2370Ilefs.
-;AA
See details at rs80359638. Note: if raw data is "DI", exact mutation may be ambiguous.
Source and license
Adapted from rs80359638 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.