rs10509680
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is G;T.
- Gene
- CYP2C9
- Location
- Chr 1094,974,582 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 3 HapMap populations.
- AverageG;G 90% G;T 10%
- European ancestry (Utah)G;G 87% G;T 13%
- Han Chinese (Beijing)G;G 88% G;T 12%
- Japanese (Tokyo)G;G 94% G;T 6%
Related
Conditions, medicines and genes
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
- rs72558189A;ACYP2C9*14 homozygoteWorth knowing
Notes
From SNPedia
Notes
Warfarin
G;T
probably impaired Warfarin metabolism.
Source and license
Adapted from rs10509680 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.