rs28371686
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is G;G: CYP2C9*5 homozygote
- Gene
- CYP2C9
- Location
- Chr 1094,981,301 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodnormal
- C;GNot ratedcarrier of one CYP2C9*5 allele
- G;GMost notableBadCYP2C9*5 homozygote
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs72558189A;ACYP2C9*14 homozygoteWorth knowing
Genosets
- Gs162CYP2C9 Poor MetabolizersImportant
- Gs161CYP2C9 Intermediate MetabolizersWorth knowing
- Gs160CYP2C9 Extensive MetabolizersMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs28371686, also known as 1080C>G, 42619C>G or D360E, is a SNP in the CYP2C9 gene. The rs28371686(G) allele defines the CYP2C9*5 variant, which appears to have decreased activity.
C;C
common for Caucasians on the 23andme platform
Source and license
Adapted from rs28371686 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.