rs72558189
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is A;A: CYP2C9*14 homozygote
- Gene
- CYP2C9
- Location
- Chr 1094,942,234 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadCYP2C9*14 homozygote
- A;GNot ratedcarrier of one CYP2C9*14 allele
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
Notes
From SNPedia
Notes
rs72558189, also known as 374G>A, 3552G>A or R125H, is a SNP in the CYP2C9 gene. The rs72558189(A) allele defines the CYP2C9*14 variant, which may have decreased activity.
Source and license
Adapted from rs72558189 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.