rs1057911
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is A;T: carrier of one CYP2C9_50298A>T allele
- Gene
- CYP2C9
- Location
- Chr 1094,988,980 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodnormal
- A;TMost notableNot ratedcarrier of one CYP2C9_50298A>T allele
- T;TNot ratedCYP2C9_50298A>T homozygote
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 93% A;T 7% T;T 0%
- European ancestry (Utah)A;A 89% A;T 11% T;T 0%
- Han Chinese (Beijing)A;A 91% A;T 9% T;T 0%
- Japanese (Tokyo)A;A 93% A;T 7% T;T 0%
- Yoruba (Nigeria)A;A 100% A;T 0% T;T 0%
Related
Conditions, medicines and genes
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
- rs72558189A;ACYP2C9*14 homozygoteWorth knowing
Notes
From SNPedia
Notes
rs1057911 is a SNP in the CYP2C9 gene. The rs1057911(T) allele defines the CYP2C9_50298A>T variant, about which little is known. Warfarin
A;T
possibly influences Warfarin dosing
T;T
possibly reduced metabolsism of warfarin and other drugs
Source and license
Adapted from rs1057911 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.