rs10759932

A SNP in the TLR4 gene on chromosome 9. Its most notable genotype is C;C: increased risk for chorionic plate inflammation

Gene
TLR4
Location
Chr 9117,702,866 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadincreased risk for chorionic plate inflammationWorth knowing · 2.05% of people
  2. C;TNot ratedincreased risk for chorionic plate inflammationTypical · 0.035% of people
  3. T;TNot ratednormalTypical · 0.060% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 5% C;T 35% T;T 60%
  • European ancestry (Utah)C;C 2% C;T 24% T;T 75%
  • Han Chinese (Beijing)C;C 5% C;T 43% T;T 52%
  • Japanese (Tokyo)C;C 9% C;T 32% T;T 59%
  • Yoruba (Nigeria)C;C 5% C;T 42% T;T 53%

Conditions, medicines and genes

Other TLR4 SNPs

All TLR4 SNPs

Notes

From SNPedia

Notes

rs10759932 is a SNP in the toll-like receptor 4 TLR4 gene. A study of 109 pregnant women focusing on TLR4 SNPs associated with chorionic plate inflammation concluded that rs10759932 was associated with increased risk when present in the mother's genome. The risk allele's increased odds ratio for clinically significant inflammation was 5.2 (CI: 3.2-6.4, p = .006)

Source and license

Adapted from rs10759932 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.