rs1927911

A SNP in the TLR4 gene on chromosome 9. Its most notable genotype is G;G: normal

Gene
TLR4
Location
Chr 9117,707,776 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.037% of people
  2. A;GNot rated0.88x lower risk of nonfatal myocardial infarctionTypical · 0.042% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people
  4. A;ANot rated0.88x lower risk of nonfatal myocardial infarctionTypical · 0.021% of people

SNPedia records rs1927911 on the minus strand: (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 37% A;G 42% C;C 0% A;A 21%
  • European ancestry (Utah)G;G 55% A;G 37% C;C 0% A;A 8%
  • Han Chinese (Beijing)G;G 37% A;G 49% C;C 0% A;A 15%
  • Japanese (Tokyo)G;G 43% A;G 46% C;C 0% A;A 12%
  • Yoruba (Nigeria)G;G 11% A;G 39% C;C 0% A;A 50%
  • African ancestry (Southwest US)G;G 18% A;G 51% C;C 0% A;A 32%
  • Chinese (Denver)G;G 42% A;G 40% C;C 0% A;A 17%
  • Gujarati IndianG;G 64% A;G 33% C;C 0% A;A 3%
  • Luhya (Kenya)G;G 15% A;G 45% C;C 0% A;A 41%
  • Mexican ancestry (Los Angeles)G;G 48% A;G 47% C;C 0% A;A 5%
  • Maasai (Kenya)G;G 17% A;G 40% C;C 0% A;A 43%
  • TuscanG;G 58% A;G 37% C;C 0% A;A 5%

Conditions, medicines and genes

Other TLR4 SNPs

All TLR4 SNPs

Notes

From SNPedia

Notes

The rs1927911(T) allele was associated with a lower risk of nonfatal myocardial infarction (odds ratio 0.88, CI: 0.77 - 0.99) in 848 patients composed of both postmenopausal women and hypertensive men/women.

Source and license

Adapted from rs1927911 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.