rs1554973

A SNP in the TLR4 gene on chromosome 9. Its most notable genotype is C;C: increased risk for chorionic plate inflammation

Gene
TLR4
Location
Chr 9117,718,534 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedincreased risk for chorionic plate inflammationWorth knowing · 2.022% of people
  2. C;TBadincreased risk for chorionic plate inflammationTypical · 0.032% of people
  3. T;TNot ratednormalTypical · 0.046% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 22% C;T 32% T;T 46%
  • European ancestry (Utah)C;C 4% C;T 35% T;T 61%
  • Han Chinese (Beijing)C;C 0% C;T 28% T;T 72%
  • Japanese (Tokyo)C;C 2% C;T 21% T;T 77%
  • Yoruba (Nigeria)C;C 71% C;T 27% T;T 2%
  • African ancestry (Southwest US)C;C 35% C;T 51% T;T 14%
  • Chinese (Denver)C;C 4% C;T 19% T;T 77%
  • Gujarati IndianC;C 11% C;T 33% T;T 56%
  • Luhya (Kenya)C;C 54% C;T 40% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 29% T;T 69%
  • Maasai (Kenya)C;C 52% C;T 40% T;T 8%
  • TuscanC;C 4% C;T 35% T;T 61%

Conditions, medicines and genes

Other TLR4 SNPs

All TLR4 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs1554973 is a SNP near the toll-like receptor 4 TLR4 gene. A study of 109 pregnant women focusing on TLR4 SNPs associated with chorionic plate inflammation concluded that rs1554973 was associated with increased risk when present in the fetal genome. The risk allele's increased odds ratio for clinically significant inflammation was 4.95 (CI: 3.0-5.6, p = .005). No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS). Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.

Source and license

Adapted from rs1554973 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.