rs12572351
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is G;G.
- Gene
- CYP2C9
- Location
- Chr 1094,943,463 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 17%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 73%
- European ancestry (Utah)G;G 72%
- Han Chinese (Beijing)G;G 42%
- Japanese (Tokyo)G;G 42%
- Yoruba (Nigeria)G;G 99%
- African ancestry (Southwest US)G;G 98%
- Chinese (Denver)G;G 56%
- Gujarati IndianG;G 55%
- Luhya (Kenya)G;G 94%
- Mexican ancestry (Los Angeles)G;G 78%
- Maasai (Kenya)G;G 90%
- TuscanG;G 79%
Related
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
Notes
From SNPedia
Notes
[Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].
Source and license
Adapted from rs12572351 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.