rs1544410

A SNP in the VDR gene on chromosome 12. Its most notable genotype is T;T: Increased risk of low bone mineral density disorders

Gene
VDR
Location
Chr 1247,846,052 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadIncreased risk of low bone mineral density disordersWorth knowing · 2.08% of people
  2. C;TNot ratedIntermediate risk of low bone mineral density disordersTypical · 0.036% of people
  3. C;CGoodDecreased risk of low bone mineral density disordersWorth knowing · 2.057% of people

SNPedia records rs1544410 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 8% C;T 36% C;C 57%
  • European ancestry (Utah)T;T 22% C;T 43% C;C 35%
  • Han Chinese (Beijing)T;T 0% C;T 7% C;C 93%
  • Japanese (Tokyo)T;T 0% C;T 21% C;C 79%
  • Yoruba (Nigeria)T;T 9% C;T 37% C;C 54%
  • African ancestry (Southwest US)T;T 0% C;T 47% C;C 53%
  • Chinese (Denver)T;T 0% C;T 8% C;C 92%
  • Gujarati IndianT;T 14% C;T 56% C;C 30%
  • Luhya (Kenya)T;T 5% C;T 38% C;C 58%
  • Mexican ancestry (Los Angeles)T;T 3% C;T 38% C;C 59%
  • Maasai (Kenya)T;T 14% C;T 47% C;C 40%
  • TuscanT;T 18% C;T 49% C;C 34%

Conditions, medicines and genes

Other VDR SNPs

All VDR SNPs

Notes

From SNPedia

Notes

rs1544410, also known as the BsmI polymorphism, is a SNP in the Vitamin D receptor (VDR). Multiple studies examining bone mineral density (BMD) in women have associated the A allele with increased risk of low BMD , , & . Additionally, A meta-analysis of 26 studies estimated a decreased risk of osteoporosis associated with the G;G genotype with an odds ratio of 0.61, 95% CI, 0.40-0.92 . rs1544410 increases susceptibility to Shorter stature for carriers of the A allele

Source and license

Adapted from rs1544410 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.