rs2107301

A SNP in the VDR gene on chromosome 12. Its most notable genotype is A;A: 2.5x higher risk for prostate cancer

Gene
VDR
Location
Chr 1247,861,787 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormal riskTypical · 0.048% of people
  2. A;GNot rated?Typical · 0.032% of people
  3. A;AMost notableBad2.5x higher risk for prostate cancerImportant · 3.019% of people

SNPedia records rs2107301 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 48% A;G 32% A;A 19%
  • European ancestry (Utah)G;G 56% A;G 36% A;A 8%
  • Han Chinese (Beijing)G;G 10% A;G 37% A;A 54%
  • Japanese (Tokyo)G;G 12% A;G 31% A;A 58%
  • Yoruba (Nigeria)G;G 78% A;G 21% A;A 1%
  • African ancestry (Southwest US)G;G 70% A;G 26% A;A 4%
  • Chinese (Denver)G;G 11% A;G 38% A;A 51%
  • Gujarati IndianG;G 49% A;G 39% A;A 13%
  • Luhya (Kenya)G;G 75% A;G 25% A;A <1%
  • Mexican ancestry (Los Angeles)G;G 53% A;G 36% A;A 10%
  • Maasai (Kenya)G;G 74% A;G 23% A;A 3%
  • TuscanG;G 46% A;G 44% A;A 10%

Conditions, medicines and genes

Other VDR SNPs

All VDR SNPs

Notes

From SNPedia

Notes

rs2107301 is a SNP in the vitamin D VDR receptor gene. rs2107301(T;T) homozygotes were associated with an ~2.5x higher risk of prostate cancer compared to homozygote carriers of the more common (C) allele in the 630 Caucasian patients studied.

A;A

For men, this has been linked to a 2.5x higher risk for prostate cancer. There isn't yet any research on women, but this is a variation in the Vitamin D receptor, and is likely to have other consequences for both sexes.

Source and license

Adapted from rs2107301 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.