rs4516035

A SNP in the VDR gene on chromosome 12. Its most notable genotype is C;C: if less milk in teenage females, less bone?

Gene
VDR
Location
Chr 1247,906,043 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedif less milk in teenage females, less bone?Typical · 0.04% of people
  2. C;TNot ratedif less milk in teenage females, less bone?Typical · 0.020% of people
  3. T;TNot ratednormalTypical · 0.076% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 4% C;T 20% T;T 76%
  • European ancestry (Utah)C;C 17% C;T 43% T;T 41%
  • Han Chinese (Beijing)C;C 0% C;T 7% T;T 93%
  • Japanese (Tokyo)C;C 0% C;T <1% T;T 99%
  • Yoruba (Nigeria)C;C 0% C;T 2% T;T 98%
  • African ancestry (Southwest US)C;C 4% C;T 16% T;T 81%
  • Chinese (Denver)C;C 0% C;T 6% T;T 94%
  • Gujarati IndianC;C 3% C;T 31% T;T 66%
  • Luhya (Kenya)C;C 0% C;T 7% T;T 93%
  • Mexican ancestry (Los Angeles)C;C 7% C;T 31% T;T 62%
  • Maasai (Kenya)C;C <1% C;T 22% T;T 78%
  • TuscanC;C 17% C;T 53% T;T 30%

Other VDR SNPs

All VDR SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

A very small study of 117 healthy European peri- and postmenarcheal girls (14.9 +/- 1.6 years) were followed for 4 years along with their calcium intake. Girls with rs4516035(C;T) and (C;C) genotypes had 13% lower spine mineral content if their milk intakes were below 260 mL/day, compared to either genotype-matched girls with higher milk intakes or to girls with the (T;T) genotype. If this is real, it suggests that rs4516035(C;T) and (C;C) female teens need more milk than rs4516035(T;T) girls to have optimal bone density. rs4516035 and the more aggressive tumour location in head-neck and trunk (OR=1.54, p=0.020)

Source and license

Adapted from rs4516035 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.