rs17110563
A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is C;C: common in complete genomics
- Gene
- TPH2
- Location
- Chr 1271,972,526 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 5 HapMap populations.
- AverageC;C 99%
- European ancestry (Utah)C;C 98%
- Han Chinese (Beijing)C;C 99%
- Japanese (Tokyo)C;C 99%
- Luhya (Kenya)C;C 98%
- Mexican ancestry (Los Angeles)C;C 98%
Related
Conditions, medicines and genes
Other TPH2 SNPs
- rs120074176C;TPossible increased risk for ADHD and other psychiatric disordersVery important
- rs1843809G;Gslightly decreased risk for ADHDMinor
- rs4570625G;Gmaybe: higher scores on anxiety-related personality traits; greater placebo responseMinor
- rs1386494A;GNo summary available.Typical
- rs4290270A;Acommon in clinvarTypical
- rs4565946C;CRisk of early-onset OCDTypical
- rs7305115A;AIndividuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotypeTypical
- rs11178997T;TNo summary available.Typical
Notes
From SNPedia
Notes
rs17110563, also known as Pro206Ser, is a SNP in the TPH2 gene. The minor allele of this SNP yielded an odds ratio of 4.8 (CI:1.6-14.8) for increased risk for bipolar disorder in a study of 883 Russian patients.
Source and license
Adapted from rs17110563 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.