rs17221417

A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is G;G: 1.9x higher risk for Crohn's disease

Gene
NOD2
Location
Chr 1650,705,671 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.080% of people
  2. C;GBad1.3x higher risk for Crohn's diseaseMinor · 1.518% of people
  3. G;GMost notableBad1.9x higher risk for Crohn's diseaseWorth knowing · 2.02% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 80% C;G 18% G;G 2%
  • European ancestry (Utah)C;C 37% C;G 56% G;G 7%
  • Han Chinese (Beijing)C;C 99% C;G <1% G;G 0%
  • Japanese (Tokyo)C;C 99% C;G <1% G;G 0%
  • Yoruba (Nigeria)C;C 97% C;G 3% G;G 0%
  • African ancestry (Southwest US)C;C 77% C;G 18% G;G 5%
  • Chinese (Denver)C;C 99% C;G <1% G;G 0%
  • Gujarati IndianC;C 82% C;G 17% G;G 1%
  • Luhya (Kenya)C;C 94% C;G 7% G;G 0%
  • Mexican ancestry (Los Angeles)C;C 66% C;G 33% G;G 2%
  • Maasai (Kenya)C;C 71% C;G 26% G;G 3%
  • TuscanC;C 56% C;G 37% G;G 7%

Conditions, medicines and genes

Other NOD2 SNPs

All NOD2 SNPs

Notes

From SNPedia

Notes

rs17221417 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.29 (CI 1.13-1.46), and for homozygotes, 1.92 (CI 1.58-2.34). Individual disease risk and multimetric analysis of Crohn disease. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

Source and license

Adapted from rs17221417 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.