rs2076756

A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is A;A: normal

Gene
NOD2
Location
Chr 1650,722,970 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.082% of people
  2. A;GNot rated?Typical · 0.017% of people
  3. G;GBad1.7x increased risk for Crohn's diseaseTypical · 0.02% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 82% A;G 17% G;G 2%
  • European ancestry (Utah)A;A 43% A;G 50% G;G 7%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 97% A;G 3% G;G 0%
  • African ancestry (Southwest US)A;A 86% A;G 9% G;G 5%
  • Chinese (Denver)A;A 99% A;G <1% G;G 0%
  • Gujarati IndianA;A 85% A;G 14% G;G 1%
  • Luhya (Kenya)A;A 90% A;G 10% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 67% A;G 31% G;G 2%
  • Maasai (Kenya)A;A 72% A;G 27% G;G <1%
  • TuscanA;A 60% A;G 36% G;G 4%

Conditions, medicines and genes

Other NOD2 SNPs

All NOD2 SNPs

Notes

From SNPedia

Show notes, about 130 words

rs2076756 is a SNP of the NOD2 gene found in a genome-wide association study to be associated with Crohn's disease. In several European populations, the minor NOD2 allele, rs2076756(G), is associated with increased risk for Crohn's disease. The odds ratio (pooled over several populations) is 1.71 (CI: 1.42-2.05, p=6x10 -8 ). Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Detecting gene-gene interactions that underlie human diseases. Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.

Source and license

Adapted from rs2076756 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.