rs2066843

A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is T;T: 4.09x higher risk for Crohn's disease

Gene
NOD2
Location
Chr 1650,711,288 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.081% of people
  2. T;TMost notableBad4.09x higher risk for Crohn's diseaseWorth knowing · 2.02% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 81% T;T 2%
  • European ancestry (Utah)C;C 41% T;T 6%
  • Han Chinese (Beijing)C;C 99% T;T 0%
  • Japanese (Tokyo)C;C 99% T;T 0%
  • Yoruba (Nigeria)C;C 97% T;T 0%
  • African ancestry (Southwest US)C;C 79% T;T 4%
  • Chinese (Denver)C;C 99% T;T 0%
  • Gujarati IndianC;C 87% T;T 0%
  • Luhya (Kenya)C;C 91% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 66% T;T 2%
  • Maasai (Kenya)C;C 73% T;T 2%
  • TuscanC;C 57% T;T 6%

Other NOD2 SNPs

All NOD2 SNPs

Notes

From SNPedia

Notes

rs2066843 increases susceptibility to Crohn's disease 4.09 times for carriers of the T allele PMID 17068223, PMID 15571588

Source and license

Adapted from rs2066843 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.