rs2066845
A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is C;C: ~35x higher risk for Crohn's disease
- Gene
- NOD2
- Location
- Chr 1650,722,629 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBad~35x higher risk for Crohn's disease
- C;GBad3x higher risk for Crohn's disease
- G;GGoodcommon in complete genomics
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other NOD2 SNPs
- rs2066847C;C35x higher risk for Crohn's diseaseVery important
- rs2066844T;TSignificance unclear; possibly higher risk for Crohn's diseaseImportant
- rs2066843T;T4.09x higher risk for Crohn's diseaseWorth knowing
- rs17221417G;G1.9x higher risk for Crohn's diseaseWorth knowing
- rs5743289C;TPerhaps increased risk for certain autoinflammatory disordersMinor
- rs2066842C;Ccommon in clinvarTypical
- rs2067085C;Ccommon in clinvarTypical
- rs2076756A;AnormalTypical
Notes
From SNPedia
Show notes, about 120 words
rs2066845 is a SNP in the NOD2 gene; this SNP is also known as c.2722G>C, G908R or Gly908Arg, with the (G) allele encoding the Gly (G) and the (C) allele encoding the Arg (R). The two initial reports linking the minor(C) allele as strongly associated with Crohn's disease are and . rs2066845 has also been reported, with an odds ratio of 3.5 (CI 1.51–7.01), to be associated with psoriatic arthritis. In a 2018 publication, rs2066845 was reported to be associated with sarcoidoisis, possibly in conjunction with other variants in the IL17RA, KALRN and EPHA2 genes. No association was found for NOD2/CARD15 SNPs (R702W, G908R) in Chinese patients with inflammatory bowel disease.
G;G
appears to be common on the 23andMe platform
Source and license
Adapted from rs2066845 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.