rs2066847
A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is C;C: 35x higher risk for Crohn's disease
- Gene
- NOD2
- Location
- Chr 1650,729,867 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon in complete genomics
- -;CBad3x higher risk of Crohn's disease
- C;CMost notableBad35x higher risk for Crohn's disease
- G;GGoodcommon on affy axiom data
On SNPedia: (-;-), (-;C), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other NOD2 SNPs
- rs2066845C;C~35x higher risk for Crohn's diseaseVery important
- rs2066844T;TSignificance unclear; possibly higher risk for Crohn's diseaseImportant
- rs2066843T;T4.09x higher risk for Crohn's diseaseWorth knowing
- rs17221417G;G1.9x higher risk for Crohn's diseaseWorth knowing
- rs5743289C;TPerhaps increased risk for certain autoinflammatory disordersMinor
- rs2066842C;Ccommon in clinvarTypical
- rs2067085C;Ccommon in clinvarTypical
- rs2076756A;AnormalTypical
Notes
From SNPedia
Notes
rs2066847 is one of several SNPs referring to a one base insertion into a run of C's within exon 11 of the NOD2 gene; the other SNPs are rs5743293 and rs112436597. The two initial reports linking this insertion variant with Crohn's disease are and . In OMIM, this insertion is allelic variant #605956.0001
Source and license
Adapted from rs2066847 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.