rs2066844

A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is T;T: Significance unclear; possibly higher risk for Crohn's disease

Gene
NOD2
Location
Chr 1650,712,015 (GRCh38)
Highest magnitude
3.1Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.096% of people
  2. C;TBadSignificance is unclear, but possibly, ~2x higher risk for Crohn's diseaseWorth knowing · 2.04% of people
  3. T;TMost notableBadSignificance unclear; possibly higher risk for Crohn's diseaseImportant · 3.10% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 96% C;T 4% T;T 0%
  • European ancestry (Utah)C;C 79% C;T 22% T;T 0%
  • Han Chinese (Beijing)C;C 98% C;T 2% T;T 0%
  • Japanese (Tokyo)C;C 99% C;T <1% T;T 0%
  • Yoruba (Nigeria)C;C 99% C;T 1% T;T 0%
  • African ancestry (Southwest US)C;C 98% C;T 2% T;T 0%
  • Chinese (Denver)C;C 99% C;T <1% T;T 0%
  • Luhya (Kenya)C;C 97% C;T 3% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 96% C;T 4% T;T 0%
  • Maasai (Kenya)C;C 99% C;T <1% T;T 0%
  • TuscanC;C 92% C;T 8% T;T 0%

Conditions, medicines and genes

Other NOD2 SNPs

All NOD2 SNPs

Notes

From SNPedia

Notes

rs2066844 is a SNP in the NOD2 gene; the SNP is also known as R702W or Arg702Trp, with the (C) allele encoding the Arg (R) and the (T) allele encoding the Trp (W). The two initial reports linking the minor(T) allele as strongly associated with Crohn's disease are and . rs2066844 is mentioned in as being strongly associated with Crohn's disease No association was found for NOD2/CARD15 SNPs (R702W, G908R) in Chinese patients with inflammatory bowel disease.

Source and license

Adapted from rs2066844 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.