rs2256871
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is G;G: CYP2C9*9 homozygote
- Gene
- CYP2C9
- Location
- Chr 1094,949,217 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 3%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2256871 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 0% A;G 4% A;A 96%
- European ancestry (Utah)G;G 0% A;G 2% A;A 99%
- Han Chinese (Beijing)G;G 0% A;G 0% A;A 100%
- Japanese (Tokyo)G;G 0% A;G 0% A;A 100%
- Yoruba (Nigeria)G;G 0% A;G 16% A;A 84%
Related
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
Genosets
- Gs162CYP2C9 Poor MetabolizersImportant
- Gs161CYP2C9 Intermediate MetabolizersWorth knowing
- Gs160CYP2C9 Extensive MetabolizersMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs2256871, also known as 752A>G, 10535A>G or H251R, is a SNP in the CYP2C9 gene. The rs2256871(C) allele defines the CYP2C9*9 variant.
Source and license
Adapted from rs2256871 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.