rs267608073
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is -;AAG: Variant of uncertain significance; possible Lynch syndrome mutation
- Gene
- MSH6
- Location
- Chr 247,801,023 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;AAGMost notableBadVariant of uncertain significance; possible Lynch syndrome mutation
- AAG;AAGGoodcommon/normal
On SNPedia: (-;AAG), (AAG;AAG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
c.3040_3042delAAG (p.Lys1014del); also reported in literature as 1013delCTT, c.3037_3039delAAG, and p.Lys1013del. 23andMe name: i5037885
-;AAG
Listed in ClinVar as being of uncertain significance, the minor allele of this genotype, causing an in-frame deletion, has been reported in individuals affected with colon, endometrial, and pancreatic cancer, but it has not been proven to be causative.
Source and license
Adapted from rs267608073 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.