rs3135499
A SNP in the NOD2 gene on chromosome 16. Its most notable genotype is A;A: common in clinvar
- Gene
- NOD2
- Location
- Chr 1650,732,216 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 39%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 36%
- European ancestry (Utah)A;A 32%
- Han Chinese (Beijing)A;A 55%
- Japanese (Tokyo)A;A 61%
- Yoruba (Nigeria)A;A 18%
- African ancestry (Southwest US)A;A 21%
- Chinese (Denver)A;A 64%
- Gujarati IndianA;A 60%
- Luhya (Kenya)A;A 13%
- Maasai (Kenya)A;A 14%
- TuscanA;A 23%
Related
Other NOD2 SNPs
- rs2066845C;C~35x higher risk for Crohn's diseaseVery important
- rs2066847C;C35x higher risk for Crohn's diseaseVery important
- rs2066844T;TSignificance unclear; possibly higher risk for Crohn's diseaseImportant
- rs2066843T;T4.09x higher risk for Crohn's diseaseWorth knowing
- rs17221417G;G1.9x higher risk for Crohn's diseaseWorth knowing
- rs5743289C;TPerhaps increased risk for certain autoinflammatory disordersMinor
- rs2066842C;Ccommon in clinvarTypical
- rs2067085C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
Source and license
Adapted from rs3135499 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.