rs4986910

A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is G;G: CYP3A4*3 homozygote

Gene
CYP3A4
Location
Chr 799,760,901 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedCYP3A4*3 homozygoteTypical · 0.00% of people
  2. A;GNot ratedcarrier of one CYP3A4*3 alleleTypical · 0.02% of people
  3. A;AGoodnormalTypical · 0.098% of people

SNPedia records rs4986910 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 0% A;G 2% A;A 98%
  • Han Chinese (Beijing)G;G 0% A;G 4% A;A 96%
  • Japanese (Tokyo)G;G 0% A;G <1% A;A 99%
  • African ancestry (Southwest US)G;G 0% A;G 2% A;A 98%
  • TuscanG;G 0% A;G 2% A;A 98%

Other CYP3A4 SNPs

All CYP3A4 SNPs

Notes

From SNPedia

Notes

rs4986910, also known as 1334T>C, 23171T>C or M445T, is a SNP in the CYP3A4 gene. The rs4986910(C) allele defines the CYP3A4*3 variant.

Source and license

Adapted from rs4986910 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.