rs4987161
A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is G;G: CYP3A4*17 homozygote
- Gene
- CYP3A4
- Location
- Chr 799,768,458 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableNot ratedCYP3A4*17 homozygote
- A;GNot ratedcarrier of one CYP3A4*17 allele
- A;AGoodnormal
SNPedia records rs4987161 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 0% A;G 0% A;A 100%
- European ancestry (Utah)G;G 0% A;G 0% A;A 100%
- Han Chinese (Beijing)G;G 0% A;G 0% A;A 100%
- Japanese (Tokyo)G;G 0% A;G 0% A;A 100%
- Yoruba (Nigeria)G;G 0% A;G 0% A;A 100%
Related
Other CYP3A4 SNPs
- rs67666821T;TCYP3A4*20 homozygote; side effects likely from many drugsVery important
- rs12721629A;ACYP3A4*12 homozygoteWorth knowing
- rs1041988G;GCYP3A4*_23139T>C(I431T) homozygoteTypical
- rs2242480C;CnormalTypical
- rs3091339T;TnormalTypical
- rs3208361T;TnormalTypical
- rs3208363C;CCYP3A4*_16907T>G(S252A) homozygoteTypical
- rs4646437G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs4987161, also known as 566T>C, 15615T>C or F189S, is a SNP in the CYP3A4 gene. The rs4987161(C) allele defines the CYP3A4*17 variant.
Source and license
Adapted from rs4987161 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.