rs587779243
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is -;GATT: Lynch syndrome, pathogenic mutation
- Gene
- MSH6
- Location
- Chr 247,800,552 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;GATTMost notableBadLynch syndrome, pathogenic mutation
- ATTG;ATTGGoodcommon in clinvar
- GATT;GATTGoodcommon/normal
On SNPedia: (-;GATT), (ATTG;ATTG), (GATT;GATT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
rs587779243, also known as c.2569_2572delGATT or p.Asp857Phefs, represents a pathogenic mutation for Lynch syndrome according to multiple ClinVar submitters.
Source and license
Adapted from rs587779243 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.