rs63750714
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is -;C: Unclear significance; possible Lynch syndrome mutation
- Gene
- MSH6
- Location
- Chr 247,803,442 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;CMost notableBadUnclear significance; possible Lynch syndrome mutation
- C;CGoodcommon/normal
On SNPedia: (-;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
c.3195delC 23andMe name: i5901028
-;C
This mutation is not listed in ClinVar, but as in frameshift mutation in the MSH6 gene, it appears likely to be as problematic as similar neighbouring mutations. Anyone with information about the pathogenicity of this mutation is encouraged to contact us.
Source and license
Adapted from rs63750714 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.