rs63751407
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is -;CT: Lynch syndrome, pathogenic mutation
- Gene
- MSH6
- Location
- Chr 247,801,035 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;CTMost notableBadLynch syndrome, pathogenic mutation
- -;TCBadLynch syndrome
- CT;CTGoodcommon in clinvar
- I;IGoodcommon genotype
- TC;TCGoodcommon in clinvar
On SNPedia: (-;CT), (-;TC), (CT;CT), (I;I), (TC;TC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
c.3053_3054delTC (p.Leu1018Hisfs) 23andMe name: i5037880 MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
Source and license
Adapted from rs63751407 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.