rs7089580
A SNP in the CYP2C9 gene on chromosome 10. Its most notable genotype is A;A.
- Gene
- CYP2C9
- Location
- Chr 1094,945,466 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 14%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 76%
- European ancestry (Utah)A;A 56%
- Han Chinese (Beijing)A;A 96%
- Japanese (Tokyo)A;A 99%
- Yoruba (Nigeria)A;A 62%
- African ancestry (Southwest US)A;A 72%
- Chinese (Denver)A;A 95%
- Gujarati IndianA;A 73%
- Luhya (Kenya)A;A 75%
- Mexican ancestry (Los Angeles)A;A 79%
- Maasai (Kenya)A;A 69%
- TuscanA;A 58%
Related
Conditions, medicines and genes
Other CYP2C9 SNPs
- rs1057909G;GCYP2C9_42612A>G homozygoteVery important
- rs1057910C;CCYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugsVery important
- rs72558188-;-inactive CYP2C9Very important
- rs1057911A;Tcarrier of one CYP2C9_50298A>T alleleImportant
- rs10509680G;TNo summary available.Important
- rs9332131-;-CYP2C9*6 homozygoteWorth knowing
- rs28371685T;TCYP2C9*11 homozygoteWorth knowing
- rs28371686G;GCYP2C9*5 homozygoteWorth knowing
Notes
From SNPedia
Notes
associations with higher warfarin dose, namely, VKORC1-8191 (rs61162043, P = 0.0041) and 18786 in CYP2C9 (rs7089580, P = 0.035) independent of the previous associations with these genes
Source and license
Adapted from rs7089580 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.