rs2258689

A SNP in the MAPT gene on chromosome 17. Its most notable genotype is C;C.

Gene
MAPT
Location
Chr 1745,990,016 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.016% of people
  2. T;TGoodcommon in clinvarTypical · 0.048% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 16% T;T 48%
  • European ancestry (Utah)C;C 3% T;T 66%
  • Han Chinese (Beijing)C;C 47% T;T 11%
  • Japanese (Tokyo)C;C 41% T;T 17%
  • Yoruba (Nigeria)C;C 1% T;T 77%
  • African ancestry (Southwest US)C;C 2% T;T 61%
  • Chinese (Denver)C;C 42% T;T 14%
  • Gujarati IndianC;C 14% T;T 40%
  • Luhya (Kenya)C;C 0% T;T 86%
  • Mexican ancestry (Los Angeles)C;C 10% T;T 47%
  • Maasai (Kenya)C;C 12% T;T 49%
  • TuscanC;C 5% T;T 61%

Other MAPT SNPs

All MAPT SNPs

Source and license

Adapted from rs2258689 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.