rs2283123
A SNP in the DBH gene on chromosome 9. Its most notable genotype is C;C: normal risk of schizophrenia in limited study
- Gene
- DBH
- Location
- Chr 9133,650,175 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 10%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot ratednormal risk of schizophrenia in limited study
- C;TGooddecreased risk of schizophrenia in limited study
- T;TGooddecreased risk of schizophrenia in limited study
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 82% C;T 17% T;T 1%
- European ancestry (Utah)C;C 76% C;T 25% T;T 0%
- Han Chinese (Beijing)C;C 77% C;T 21% T;T 2%
- Japanese (Tokyo)C;C 85% C;T 14% T;T <1%
- Yoruba (Nigeria)C;C 92% C;T 8% T;T 0%
- African ancestry (Southwest US)C;C 90% C;T 11% T;T 0%
- Chinese (Denver)C;C 83% C;T 17% T;T 0%
- Gujarati IndianC;C 60% C;T 32% T;T 8%
- Luhya (Kenya)C;C 84% C;T 16% T;T 0%
- Mexican ancestry (Los Angeles)C;C 91% C;T 9% T;T 0%
- Maasai (Kenya)C;C 82% C;T 18% T;T <1%
- TuscanC;C 77% C;T 22% T;T 1%
Related
Conditions, medicines and genes
Other DBH SNPs
- rs2007153T;Tdecreased risk of schizophrenia in limited studyMinor
- rs4531G;Gcommon on affy axiom dataTypical
- rs5320G;Gcommon in complete genomicsTypical
- rs6271C;Ccommon in clinvarTypical
- rs77905A;Acommon in clinvarTypical
- rs129882C;Ccommon in clinvarTypical
- rs1108580A;Acommon in clinvarTypical
- rs1611115C;CnormalTypical
Notes
From SNPedia
Notes
Associated with schizophrenia in a study of Croatians. Due to the limited number and diversity of the studied population, more study is needed to confirm any link. The T allele was associated with a decreased risk of schizophrenia.
Source and license
Adapted from rs2283123 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.