rs6271
A SNP in the DBH gene on chromosome 9. Its most notable genotype is C;C: common in clinvar
- Gene
- DBH
- Location
- Chr 9133,657,152 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 7 HapMap populations.
- AverageC;C 95%
- European ancestry (Utah)C;C 88%
- Han Chinese (Beijing)C;C 100%
- Japanese (Tokyo)C;C 100%
- Yoruba (Nigeria)C;C 100%
- African ancestry (Southwest US)C;C 98%
- Mexican ancestry (Los Angeles)C;C 86%
- TuscanC;C 91%
Related
Other DBH SNPs
- rs2007153T;Tdecreased risk of schizophrenia in limited studyMinor
- rs2283123C;Cnormal risk of schizophrenia in limited studyMinor
- rs4531G;Gcommon on affy axiom dataTypical
- rs5320G;Gcommon in complete genomicsTypical
- rs77905A;Acommon in clinvarTypical
- rs129882C;Ccommon in clinvarTypical
- rs1108580A;Acommon in clinvarTypical
- rs1611115C;CnormalTypical
Notes
From SNPedia
Notes
aka c.1645C>T, p.Arg549Cys and R549C An in vitro functional study concluded that rs6271 (R549C) exhibited both decreased homospecific activity and differential secretion compared to a wild-type (normal) control.
Source and license
Adapted from rs6271 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.