rs10489629
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is T;T: 0.83x lower risk for spondylitis
- Gene
- IL23R
- Location
- Chr 167,222,666 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 45%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot rated0.83x lower risk for spondylitis
- C;TNot rated0.83x lower risk for spondylitis
- C;CNot ratednormal risk
SNPedia records rs10489629 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 34% C;T 46% C;C 20%
- European ancestry (Utah)T;T 30% C;T 45% C;C 25%
- Han Chinese (Beijing)T;T 50% C;T 42% C;C 7%
- Japanese (Tokyo)T;T 50% C;T 38% C;C 12%
- Yoruba (Nigeria)T;T 25% C;T 44% C;C 32%
- African ancestry (Southwest US)T;T 19% C;T 58% C;C 23%
- Chinese (Denver)T;T 51% C;T 46% C;C 3%
- Gujarati IndianT;T 53% C;T 39% C;C 9%
- Luhya (Kenya)T;T 18% C;T 50% C;C 32%
- Mexican ancestry (Los Angeles)T;T 21% C;T 43% C;C 36%
- Maasai (Kenya)T;T 21% C;T 53% C;C 26%
- TuscanT;T 31% C;T 53% C;C 16%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
Notes
From SNPedia
Notes
rs10489629 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.83 (p=0.00014).PMID 17952073, PMID 18037607
Source and license
Adapted from rs10489629 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.